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| Bioactivity: | Beta-Amyloid (1-40)(Human) is the predominant proteolytic product of amyloid precursor protein (APP) processing and constitutes approximately 90% of secreted Aβ species. It is a primary component of senile plaques and cerebral amyloid angiopathy in Alzheimer’s disease pathology. Aβ(1-40) forms cation-selective ion channels in lipid bilayers and exhibits concentration-dependent neurotrophic and neurotoxic effects in neuronal cultures. The peptide serves as a validated reference standard for sandwich-type enzyme immunoassays quantifying amyloid-A4 protein in cerebrospinal fluid. Structural studies demonstrate transition from random coil to α-helical conformation in water-micelle environments, with a C-terminal membrane insertion domain facilitating interaction with lipid bilayers. |
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| Three-letter Sequence: | H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH |
| Appearance: | White lyophilized powder |
| Counter Ion: | Trifluoroacetate (TFA) |
| Storage: | Store at -20°C or below upon receipt. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles by aliquoting the peptide upon first reconstitution. |
| Reconstitution: | Dissolve in sterile distilled water, PBS |
| Shipping: | All peptides will be shipped as lyophilized powder with desiccant at room temperature. |
