Overview

NovoPep specializes in full-spectrum chemical peptide synthesis powered by Fmoc solid-phase and solution-phase technologies. From simple linear sequences to highly complex modified peptides, we deliver fully customized solutions precisely aligned with your unique research goals.

With 12 years of experience supporting scientists worldwide, NovoPep offers reliable custom peptide synthesis services designed to help you get better results faster — and save money along the way.

Strict Quality Control You Can Trust

Every peptide produced at NovoPep goes through standardized reverse-phase HPLC purification and mass spectrometry identity verification. Full analytical reports containing all test data will be delivered together with your products, to ensure every batch meets your required purity and structural consistency.

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A trusted high-quality synthetic peptide supplier you can count on:

For over 12 years, NovoPep has been the go-to reliable custom peptide synthesis provider for ‌a large number of global scientists, dedicated to getting you better research results quickly and at a budget-friendly price.

Services & Capabilities                                                              High Purity & High Success Rate

Simple to complex                                                                       Purities: from crude to > 98% purity. 

Linear Peptides and Cyclic Peptides                                            HPLC trace and mass spectrum with every peptide

Long sequences peptide up to 200 mer                                      High Success Rate: greater than 95%.

Flexible Scale & Fast Turnaround                                              Peptide Modifications

From milligram to kilogram quantities                                         Acetylation/Amidation free of charge

Standard peptides delivered in 2–3 weeks                                   Fluorescent labeling: FAM, FITC, TAMRA

Expedited services available for urgent projects                          Isotope labeling (N15, C13)

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TFA Exchange Services

Trifluoroacetic acid (TFA) is a strong acid commonly used to cleave peptides from solid-phase resins and boost HPLC performance during purification. That means standard custom peptides arrive as lyophilized TFA salts, with TFA content that can hit 10–45%. 

Residual TFA in custom peptides can introduce unaccounted, unexplained variability in downstream assay results. Studies have demonstrated that even nanomolar-level TFA interferes with cellular assays, inhibiting cell proliferation in some experimental setups while boosting cell viability in others. It has also been identified as an unintended allosteric modulator of the glycine receptor (GlyR).

Our TFA Removal Service is highly recommended for four core scenarios: 

● Cellular assays

● Industry product

● Immunotherapy research

● Protein/peptide structure study

The most optimized and reliable approach is to substitute TFA counterions with a stronger acid such as hydrochloric acid (HCl). Exchanging TFA to acetate is also commonly used.

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Recommended peptide purity

At NovoPep, we offer a full spectrum of peptide purity grades tailored to match the exact requirements of your peptide-based assays and research applications. Below you will find our recommended purity guidelines for common experimental use cases — every tier is fully accessible through our custom peptide synthesis services.

Every peptide from NovoPep undergoes strict dual quality verification via HPLC and mass spectrometry, with full QC documentation included in every order shipment.

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Standard QC Tests Included for All Custom Peptides

Every peptide, regardless of scale or purity grade, comes with these mandatory, no-extra-cost analytical validations:

● ‌‌ High-Performance Liquid Chromatography (HPLC): Reversed-phase C18 high-performance liquid chromatography at 220 nm UV detection, with peptide-specific elution gradients to calculate exact purity via peak area integration.

●  Electrospray Ionization Mass Spectrometry (ESI-MS)‌‌: Electrospray ionization mass spectrometry that cross-checks the observed molecular weight against your theoretical peptide sequence, 100% eliminating truncation or sequence error risks.

●  Full Certificate of Analysis (COA)‌: A complete Certificate of Analysis logging batch number, synthesis records, final purity, net peptide content, and recommended storage conditions

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Peptide Synthesis Methods

At NovoPep, our custom peptide synthesis capabilities cover research‑grade peptides through to API‑grade peptide manufacturing. We leverage multiple established synthetic approaches to accommodate diverse project requirements, sequence complexities and end‑application goals.

Liquid‑phase peptide synthesis is well‑suited for producing short‑chain peptides such as dipeptides.

Solid‑phase peptide synthesis enables the production of bioactive peptides, including challenging sequences: long peptides, difficult‑to‑assemble peptides, and highly hydrophobic peptide targets.

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How to Request a Quote

To prepare an accurate and tailored quotation, please share the key details of the peptides to be synthesized:

You can request a quote via email to service@novopep.com, our team will provide a detailed quote within 2–24 hours.