β-Amyloid (25-35)

Cat.No.：NP020502-ABT2535

Description：β-Amyloid (25-35) is a chemically synthesized human amyloid beta peptide fragment spanning residues 25 to 35.

Product Name：β-Amyloid (25-35)
Synonym：Aβ25-35 | Aβ 25-35 | Abeta25-35 | AB25-35 | Amyloid β-Peptide (25-35) | Amyloid β-Protein (25-35) | Amyloid beta 25-35 | Amyloid beta (25-35) | beta-Amyloid (25-35) | beta-Amyloid peptide (25-35) | β-Amyloid-25-35 | β-Amyloid (25-35) | BetaAPP25-35 | BAPP25-35 | βAPP25-35B | APP25-35 | BAP 25-35 | A-BETA(25-35) | DA-25-35 | Amyloid β Protein Fragment 25-35
Sequence：GSNKGAIIGLM
Cas No.：131602-53-4
Molecular Weight：1060.26
Price (USD)：$150.00/5mg; $250.00/10mg;$400.00/20mg

All products are for scientific research purposes only and cannot be used for personal purposes.

Bioactivity:	β-Amyloid (25-35) is a neurotoxic fragment of the amyloid-beta peptide strongly implicated in Alzheimer’s disease pathogenesis. In vitro, Aβ(25-35) induces apoptotic effects on isolated brain mitochondria, generates reactive oxygen species (ROS), and triggers neuronal cell death pathways. The peptide promotes amyloid fibril formation and has been extensively used to establish both cellular and animal models of Alzheimer’s disease. Intracerebroventricular injection of Aβ(25-35) in rodents produces robust spatial learning and memory impairments, making it a gold-standard reagent for evaluating cognitive dysfunction and screening potential therapeutics. The oxidation state of Met35 is critical for its toxic activity — methionine oxidation at this position significantly modulates fibrillogenesis and cellular toxicity. This fragment serves as an indispensable tool in studies of amyloid-induced neurodegeneration, metal-peptide interactions, copper/zinc-mediated oxidative damage, and antioxidant therapy screening.
Three-letter Sequence:	Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
Appearance:	Lyophilized white powder
Counter Ion:	TFA
Storage:	Power: -20°C(1 year) or -80°C(1~2 years)
Reconstitution:	ACN/water (1:2) or DMSO
Shipping:	All peptides will be shipped as lyophilized powder with desiccant at room temperature.

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