β-Amyloid (1-42) (Human), TFA

Cat.No.：NP020601-ABT42

Description：β-Amyloid (1-42) (Human) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

Product Name：β-Amyloid (1-42) (Human), TFA
Synonym：Aβ1-42 | Aβ 1-42 | Abeta42 | AB42 | Amyloid β-Peptide (1-42) | Amyloid β-Protein (1-42) | Amyloid beta 1-42 | Amyloid beta (1-42) | beta-Amyloid (1-42) | beta-Amyloid peptide (1-42) | β-Amyloid-42 | β-Amyloid (1-42) | BetaAPP42 | BAPP42 | βAPP42B | APP42 | BAP 1-42 | A-BETA(1-42) | DA-42 | Amyloid β Protein Fragment 1-42
Sequence：DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Cas No.：107761-42-2
Molecular Weight：4514.04
Price (USD)：$150.00/1mg; $400.00/5mg; $650.00/10mg

All products are for scientific research purposes only and cannot be used for personal purposes.

Bioactivity:	β-Amyloid (1-42) is widely recognized as the most pathogenic isoform of the amyloid beta peptide and a primary constituent of senile plaques in the brains of Alzheimer's disease patients. The two additional C-terminal hydrophobic residues (isoleucine and leucine) compared to Aβ1-40 confer a markedly higher propensity for self-aggregation, beta-sheet formation, and oligomerization — properties directly implicated in neuronal dysfunction and apoptosis. This peptide is extensively employed in studies of amyloid nucleation-dependent polymerization, protofibril and oligomer characterization, metal ion coordination chemistry, and as an immunogen for generating conformation-specific antibodies. It is also utilized in high-throughput drug screening platforms designed to identify small-molecule inhibitors of amyloid assembly and in cell-based neurotoxicity models including SH-SY5Y, PC12, and primary hippocampal neuronal cultures.
Three-letter Sequence:	Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile- Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Appearance:	White lyophilized powder
Counter Ion:	Trifluoroacetate (TFA)
Storage:	Power: -20°C(1 year) or -80°C(1~2 years) ; In solvent: -20°C(1 month) or -80°C(5~6 months)
Reconstitution:	Acetic acid/water (3:2) or DMSO
Shipping:	All peptides will be shipped as lyophilized powder with desiccant at room temperature.

NAME：ACS Biomaterials Science & Engineering; Vol 9/Issue 4; 2022.

Publication date： 2022

Reference product： β-Amyloid (1-42) (Human), TFA(NP020601-ABT42)

Q：What is the usage method of this product?
A:Prevent the use of open flames, normal temperature is sufficient